Proteins Regulate Blood SugarThe Diabetes Site
By Kathleen Blanchard RN for eMaxHealth.com
A new protein discovery could become a new target for treating diabetes. What scientists have discovered is that A-kinase anchoring proteins or AKAPs influence levels of glucose in the body in a first discovery. The researchers say the new finding means they can move forward to develop drugs that interfere with the protein’s function.
For their study the researchers used imaging techniques combined with genetically modified insulin cells and whole mice. They found that mice lacking AKAP150 anchoring protein didn’t produce as much insulin from beta cells in the pancreas, but they had better insulin sensitivity in skeletal muscles. The scientists were able to show glucose control came from a seven-amino-acid sequence in the anchor protein that directly interacts with the surface of phosphatase enzyme.
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